abstract：OBJECTIVE:To compare the short-term effects of adaptive support ventilation (ASV), an advanced closed-loop mode, with conventional volume or pressure-control ventilation in patients passively ventilated for acute respiratory failure. DESIGN:Prospective crossover interventional multicenter trial. SETTING:Six European ...

journal_title：Intensive care medicine

authors： Iotti GA,Polito A,Belliato M,Pasero D,Beduneau G,Wysocki M,Brunner JX,Braschi A,Brochard L,Mancebo J,Ranieri VM,Richard JC,Slutsky AS

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Adverse respiratory and gasometrical effects have been described in patients with acute respiratory failure (ARF) undergoing noninvasive ventilation (NIV) with standard heat and moisture exchangers (HME). We decided to evaluate respiratory parameters and arterial blood gases (ABG) of patients during NIV with ...

journal_title：Intensive care medicine

authors： Boyer A,Vargas F,Hilbert G,Gruson D,Mousset-Hovaere M,Castaing Y,Dreyfuss D,Ricard JD

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:We compared 1 versus 0.5 microg/kg bolus remifentanil versus placebo in alleviating pain due to chest drain removal. Effects on sedation, respiratory rate (RR), oxygen saturation, heart rate (HR) and blood pressure were also evaluated. METHODS:Sixty patients following cardiac surgery were enrolled in this pros...

journal_title：Intensive care medicine

authors： Casey E,Lane A,Kuriakose D,McGeary S,Hayes N,Phelan D,Buggy D

更新日期：2010-08-01 00:00:00

abstract：:The endothelium is a highly dynamic cell layer that is involved in a multitude of physiological functions, including the control of vascular tone, the movement of cells and nutrients, the maintenance of blood fluidity and the growth of new vessels. During severe sepsis, the endothelium becomes proadhesive, procoagulan...

journal_title：Intensive care medicine

authors： Ait-Oufella H,Maury E,Lehoux S,Guidet B,Offenstadt G

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Infection is the most frequent cause of acute respiratory distress syndrome (ARDS). However, little is known about the influence of infection sites on ARDS. This study aimed to assess the associations of infection sites with ARDS development and mortality in critically ill infected patients. DESIGN:Prospecti...

journal_title：Intensive care medicine

authors： Sheu CC,Gong MN,Zhai R,Bajwa EK,Chen F,Thompson BT,Christiani DC

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:There is still a lack of knowledge on the age-dependent relation between a reduction in cerebral perfusion pressure (CPP) and compromised brain perfusion leading to excessive transmitter release and brain damage cascades. The hypothesis is that an age-dependent lower threshold of cerebral blood flow (CBF) aut...

journal_title：Intensive care medicine

authors： Walter B,Aisenpreis K,Fritz HG,Soukup J,Eiselt M,Bauer R

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Pneumonia associated with invasive mechanical ventilation (IMV) is one of the indicator infections of the German Nosocomial Infection Surveillance System. In 2005 surveillance was extended to include pneumonia associated with noninvasive ventilation (NIV). The aim of this study was to determine the utilization ...

journal_title：Intensive care medicine

authors： Kohlenberg A,Schwab F,Behnke M,Geffers C,Gastmeier P

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:After resuscitation, asphyxiated neonates often develop poor cardiac function with hypotension, pulmonary hypertension and multiorgan ischemia. In a swine model of neonatal hypoxia-reoxygenation, effects of epinephrine, dobutamine and milrinone on systemic, pulmonary and regional hemodynamics and oxygen tran...

journal_title：Intensive care medicine

authors： Joynt C,Bigam DL,Charrois G,Jewell LD,Korbutt G,Cheung PY

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Pulmonary hypertension is a characteristic feature of acute respiratory distress syndrome (ARDS) and contributes to mortality. Administration of sildenafil in ambulatory patients with pulmonary hypertension improves oxygenation and ameliorates pulmonary hypertension. Our aim was to determine whether sildenafi...

journal_title：Intensive care medicine

authors： Cornet AD,Hofstra JJ,Swart EL,Girbes AR,Juffermans NP

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To provide recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza pandemic or mass disaster with a specific focus on essential equipment, pharmaceuticals and supplies. METHODS:Based on a literature review and expert opinion, a Delphi process was use...

journal_title：Intensive care medicine

authors： Sprung CL,Kesecioglu J,European Society of Intensive Care Medicine's Task Force for intensive care unit triage during an influenza epidemic or mass disaster.

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:To investigate whether ultrasound determination of the inferior vena cava diameter (IVCD) and its collapsibility index (IVCCI) could be used to optimize the fluid removal rate while avoiding hypotension during slow continuous ultrafiltration (SCUF). METHODS:Twenty-four consecutive patients [13 men and 11 wom...

journal_title：Intensive care medicine

authors： Guiotto G,Masarone M,Paladino F,Ruggiero E,Scott S,Verde S,Schiraldi F

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:To compare the ventilation achieved with chest compressions (CC) or ventilation plus compressions (VC) in a pediatric animal model of cardiac arrest. DESIGN:Randomized experimental study. SETTING:Experimental department of a University Hospital. METHODS:Twelve infant pigs with asphyxial cardiac arrest. Seq...

journal_title：Intensive care medicine

authors： Iglesias JM,López-Herce J,Urbano J,Solana MJ,Mencía S,Del Castillo J

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:Rapid shallow breathing may occur at any time during spontaneous breathing trials (SBT), questioning the utility of a single determination of the rapid shallow breathing index (RSBI). We hypothesize that change in RSBI during SBT may more accurately predict successful extubation than a single determination. ME...

journal_title：Intensive care medicine

authors： Segal LN,Oei E,Oppenheimer BW,Goldring RM,Bustami RT,Ruggiero S,Berger KI,Fiel SB

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To provide recommendations and standard operating procedures for intensive care units and hospital preparedness for an influenza pandemic. METHODS:Based on a literature review and expert opinion, a Delphi process was used to define the essential topics. RESULTS:Key recommendations include: Hospitals should in...

journal_title：Intensive care medicine

authors： Sprung CL,Zimmerman JL,Christian MD,Joynt GM,Hick JL,Taylor B,Richards GA,Sandrock C,Cohen R,Adini B,European Society of Intensive Care Medicine Task Force for Intensive Care Unit Triage during an Influenza Epidemic or Mass Disaster.

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:We determined the effects of two antibiotic policies (predominance of either beta-lactam antibiotics or fluroquinolones) on acquisition with third-generation cephalosporin-resistant Enterobacteriaceae (CRE) and fluoroquinolone-resistant CRE (FCRE) in two ICUs, with monitoring of other variables that may infl...

journal_title：Intensive care medicine

authors： Nijssen S,Fluit A,van de Vijver D,Top J,Willems R,Bonten MJ

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:Assessing pulse pressure variation (PPV) to predict fluid responsiveness in mechanically ventilated patients with tidal volume (VT) and the impact of VT and airway driving pressure (P(plat) - PEEP) on the ability of PPV for predicting fluid responsiveness. DESIGN:Prospective interventional study. SETTING:IC...

journal_title：Intensive care medicine

authors： Muller L,Louart G,Bousquet PJ,Candela D,Zoric L,de La Coussaye JE,Jaber S,Lefrant JY

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:The emphasis on the importance of professionalism in a recent CoBaTrICE-IT paper was impressive. However, insight into the elements of professionalism as perceived relevant for intensivists from the fellows' view, and how these are taught and learned, is limited. OBJECTIVES AND METHODS:A nationwide study ...

journal_title：Intensive care medicine

authors： van Mook WN,de Grave WS,Gorter SL,Muijtjens AM,Zwaveling JH,Schuwirth LW,van der Vleuten CP

更新日期：2010-02-01 00:00:00

abstract：:Arterial catheterization is the second most common invasive procedure performed in the intensive care unit. Despite the ubiquity of the procedure, complications including failure to place the catheter occur. While many clinicians are familiar with the use of ultrasound (US) guidance to decrease complication rates of c...

journal_title：Intensive care medicine

authors： Shiloh AL,Eisen LA

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To apply the modified pediatric RIFLE criteria for severity of acute kidney injury (AKI) to pediatric burn ICU patients and to evaluate the overall incidence of AKI, risk factors for AKI and influence of AKI on outcome. DESIGN:Retrospective, descriptive cohort study. SETTING:10-bed burn PICU facility. PATI...

journal_title：Intensive care medicine

authors： Palmieri T,Lavrentieva A,Greenhalgh D

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:To assess the generalisability of published clinical risk predictive models for invasive candidiasis in ICU patients. METHODS:The performance characteristics of published clinical risk factor-only and Candida colonisation-only predictive models for invasive candidiasis were assessed in a multicentre cohort of ...

journal_title：Intensive care medicine

authors： Playford EG,Lipman J,Kabir M,McBryde ES,Nimmo GR,Lau A,Sorrell TC

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:Invasive candidiasis (IC) outcomes in intensive care units (ICUs) could be improved by the early administration of antifungals. The Candida Score (CS) prediction rule has been proposed for the selection of patients who could develop IC. Procalcitonin (PCT) levels allow prompt identification of sepsis, but the...

journal_title：Intensive care medicine

authors： Charles PE,Castro C,Ruiz-Santana S,León C,Saavedra P,Martín E

更新日期：2009-12-01 00:00:00

abstract：INTRODUCTION:Microcirculatory abnormalities are frequently observed in patients with severe heart failure and correlate to worse outcomes. We tested the hypothesis that nitroglycerin dose-dependently improves perfusion in severe heart failure and that this could be monitored by measuring central-peripheral temperature ...

journal_title：Intensive care medicine

authors： den Uil CA,Caliskan K,Lagrand WK,van der Ent M,Jewbali LS,van Kuijk JP,Spronk PE,Simoons ML

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To determine the oxygen affinity for optimal tissue oxygen delivery with a hemoglobin-hydroxyethyl starch conjugate (HRC 101). METHODS:Anesthetized rats were hemodiluted (180 ml kg(-1)) with low (P(50) approximately 70 mmHg) or high affinity (P(50) approximately 14 mmHg) HRC 101 at hemoglobin (Hb) concentratio...

journal_title：Intensive care medicine

authors： Hare GM,Liu E,Baker AJ,Mazer CD

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:During neurally adjusted ventilatory assist (NAVA) the ventilator is driven by the patients electrical activation of the diaphragm (EAdi), detected by a special esophageal catheter. A reliable positioning of the EAdi-catheter is mandatory to trace a representative EAdi signal. We aimed to determine whether a fo...

journal_title：Intensive care medicine

authors： Barwing J,Ambold M,Linden N,Quintel M,Moerer O

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:To determine the incidence rates of hospital acquired infections (HAI) during the first 14 days after ICU discharge after treatment during ICU-stay with Selective Decontamination of the Digestive tract (SDD), Selective Oropharyngeal Decontamination (SOD) or Standard Care (SC). DESIGN:Prospective observationa...

journal_title：Intensive care medicine

authors： de Smet AM,Hopmans TE,Minderhoud AL,Blok HE,Gossink-Franssen A,Bernards AT,Bonten MJ

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Type 1 angiotensin II (AT1) receptor antagonists have anti-inflammatory effects in vitro and in patients. The purpose of this study was to investigate whether losartan (LOS), an AT1 receptor antagonist, reduces lung damage by inhibiting the induction of high mobility group box 1 (HMGB1) protein and cytokines by...

journal_title：Intensive care medicine

authors： Hagiwara S,Iwasaka H,Hidaka S,Hasegawa A,Koga H,Noguchi T

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To describe the course of early organ dysfunction in a cohort of patients admitted in ICU suffering classic heatstroke. METHODS:Prospective observational single-centre cohort study with a 1-year follow-up. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:Clinical and biological data of 22 patients were anal...

journal_title：Intensive care medicine

authors： Pease S,Bouadma L,Kermarrec N,Schortgen F,Régnier B,Wolff M

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:In critical illness, serum total cortisol (TC) may not adequately reflect adrenal function because of reduced cortisol-binding globulin (CBG). AIM:To evaluate adrenal function of critically ill children, using free cortisol index (FCI), calculated free cortisol (cFC), and TC levels. METHODS:Thirty-two crit...

journal_title：Intensive care medicine

authors： Poomthavorn P,Lertbunrian R,Preutthipan A,Sriphrapradang A,Khlairit P,Mahachoklertwattana P

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:Assessing feasibility and physiological effects of sedation with sevoflurane, administered with the anesthetic conserving device (AnaConDa), in comparison with propofol and remifentanil. METHODS:Seventeen patients undergoing mechanical ventilation underwent sedation with sevoflurane delivered with AnaConDa (ph...

journal_title：Intensive care medicine

authors： Migliari M,Bellani G,Rona R,Isgrò S,Vergnano B,Mauri T,Patroniti N,Pesenti A,Foti G

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the ability of DeltaPP/DeltaP [pulse pressure variations (DeltaPP) adjusted by alveolar pressure variations (DeltaP = Pplat-PEEPtot)] in predicting fluid responsiveness, to compare its accuracy to that of DeltaPP used alone and to evaluate the influence of tidal volume (Vt) on these two indices. ...

journal_title：Intensive care medicine

authors： Vallée F,Richard JC,Mari A,Gallas T,Arsac E,Verlaan PS,Chousterman B,Samii K,Genestal M,Fourcade O

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:Gastrointestinal motility can be impaired by serious illness or medications, compromising enteral feeding in critical care patients. We compared small bowel transit time and morphology in neurosurgical critical care (ICU) patients with those in healthy subjects. METHODS:We evaluated small intestinal transit ti...

journal_title：Intensive care medicine

authors： Rauch S,Krueger K,Turan A,Roewer N,Sessler DI

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Angiopoietin-2 (Ang-2) is a potent regulator of vascular permeability and inflammation in acute lung injury and acute respiratory distress syndrome (ARDS). Genetic variants in the Ang-2 gene may lead to altered activities of Ang-2 (or ANGPT2) gene. The aim of this study was to assess if genetic variants of An...

journal_title：Intensive care medicine

authors： Su L,Zhai R,Sheu CC,Gallagher DC,Gong MN,Tejera P,Thompson BT,Christiani DC

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To assess the role of antipseudomonal agents on Pseudomonas aeruginosa colonization and acquisition of resistance. DESIGN:Prospective cohort study. SETTING:Two medical intensive care units. PATIENTS AND PARTICIPANTS:346 patients admitted for >or= 48 h. INTERVENTION:Analysis of data from an 8-month study c...

journal_title：Intensive care medicine

authors： Martínez JA,Delgado E,Martí S,Marco F,Vila J,Mensa J,Torres A,Codina C,Trilla A,Soriano A,Alquezar A,Castro P,Nicolás JM

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:It remains uncertain why immunocompetent patients with bacterial community-acquired pneumonia (CAP) die, in spite of adequate antibiotics. METHODS:This is a secondary analysis of the CAPUCI database which was a prospective observational multicentre study. Two hundred and twelve immunocompetent patients admi...

journal_title：Intensive care medicine

authors： Rodriguez A,Lisboa T,Blot S,Martin-Loeches I,Solé-Violan J,De Mendoza D,Rello J,Community-Acquired Pneumonia Intensive Care Units (CAPUCI) Study Investigators.

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of respiratory physiotherapy on the prevention and treatment of ventilator-associated pneumonia (VAP) for adults in an intensive care unit (ICU) with an acquired brain injury (ABI). DESIGN AND SETTING:Two-part, prospective, randomised controlled trial. PATIENTS:A total of 144 subje...

journal_title：Intensive care medicine

authors： Patman S,Jenkins S,Stiller K

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:The role of haemofiltration as an adjunctive treatment of sepsis remains a contentious issue. To address the role of dose and to explore the biological effects of haemofiltration we compared the effects of standard and high-volume haemofiltration (HVHF) in a peritonitis-induced model of porcine septic shock. ...

journal_title：Intensive care medicine

authors： Sykora R,Chvojka J,Krouzecky A,Radej J,Karvunidis T,Varnerova V,Novak I,Matejovic M

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was (1) to determine the prevalence of intensive care unit (ICU) admissions due to an adverse drug reaction (ADR), and (2) to compare affected patients with patients admitted to the ICU for the treatment of deliberate self-poisoning using medical drugs. DESIGN:Prospective observa...

journal_title：Intensive care medicine

authors： Schwake L,Wollenschläger I,Stremmel W,Encke J

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Invasive candidiasis and candidemia are frequently encountered in the nosocomial setting particularly in the intensive care unit (ICU). OBJECTIVE AND METHODS:To review the current management of invasive candidiasis and candidemia in non-neutropenic adult ICU patients based on a review of the literature and ...

journal_title：Intensive care medicine

authors： Guery BP,Arendrup MC,Auzinger G,Azoulay E,Borges Sá M,Johnson EM,Müller E,Putensen C,Rotstein C,Sganga G,Venditti M,Zaragoza Crespo R,Kullberg BJ

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:We propose that higher airway occlusion pressure (P0.1) responses to hypercapnic challenge (HC) indicate less severe injury. The study aim was to determine whether P0.1 responses to HC were associated with successful weaning after prolonged mechanical ventilation (PMV) in patients with brainstem lesions and t...

journal_title：Intensive care medicine

authors： Wu YK,Lee CH,Shia BC,Tsai YH,Tsao TC

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effectiveness of an enhanced software Model Predictive Control (eMPC) algorithm for intravenous insulin infusion, targeted at tight glucose control in critically ill patients, over 72 h, in two intensive care units with different management protocols. DESIGN:Comparison with standard care i...

journal_title：Intensive care medicine

authors： Cordingley JJ,Vlasselaers D,Dormand NC,Wouters PJ,Squire SD,Chassin LJ,Wilinska ME,Morgan CJ,Hovorka R,Van den Berghe G

更新日期：2009-01-01 00:00:00